X Chromosome and Autosome Dosage Responses in Drosophila melanogaster Heads
| Autor: | Brian Oliver, Zhen-Xia Chen |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
X Chromosome Molecular Sequence Data sex determination Biology segmental aneuploidy Gene dosage X-inactivation X hyperactivation 03 medical and health sciences 0302 clinical medicine Dosage Compensation Genetic Databases Genetic Genetics Animals X:A ratio Molecular Biology Genetics (clinical) X chromosome 030304 developmental biology Allosome 0303 health sciences Dosage compensation Autosome Sequence Analysis RNA sex chromosomes Chromosomes Insect Genetics of Sex Drosophila melanogaster dosage compensation gene expression Female Head 030217 neurology & neurosurgery |
| Zdroj: | G3: Genes|Genomes|Genetics |
| ISSN: | 2160-1836 |
| DOI: | 10.1534/g3.115.017632 |
| Popis: | X chromosome dosage compensation is required for male viability in Drosophila. Dosage compensation relative to autosomes is two-fold, but this is likely to be due to a combination of homeostatic gene-by-gene regulation and chromosome-wide regulation. We have baseline values for gene-by-gene dosage compensation on autosomes, but not for the X chromosome. Given the evolutionary history of sex chromosomes, these baseline values could differ. We used a series of deficiencies on the X and autosomes, along with mutations in the sex-determination gene transformer-2, to carefully measure the sex-independent X-chromosome response to gene dosage in adult heads by RNA sequencing. We observed modest and indistinguishable dosage compensation for both X chromosome and autosome genes, suggesting that the X chromosome is neither inherently more robust nor sensitive to dosage change. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|