Cutting Edge: Lymphoid Tissue Inducer Cells Maintain Memory CD4 T Cells within Secondary Lymphoid Tissue
| Autor: | Graham Anderson, Clare L. Marriott, Ewan A. Ross, Adriana Flores-Langarica, David R. Withers, Emma C. Mackley, Peter J. L. Lane, Guillaume E. Desanti, Andrea J. White, Natalie A. Roberts, Fabrina Gaspal, Fiona M. McConnell |
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| Rok vydání: | 2012 |
| Předmět: |
Cell Survival
Lymphoid Tissue Immunology Mice Transgenic Adaptive Immunity Biology Article Mice Interleukin 21 Lymphopenia Animals Immunology and Allergy Cytotoxic T cell IL-2 receptor Antigen-presenting cell Interleukin 3 Mice Knockout Cell Death ZAP70 Innate lymphoid cell T-Lymphocytes Helper-Inducer Nuclear Receptor Subfamily 1 Group F Member 3 Natural killer T cell Immunity Innate Cell biology Mice Inbred C57BL Radiation Chimera Immunologic Memory |
| Zdroj: | The Journal of Immunology. 189:2094-2098 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.1201639 |
| Popis: | Phylogeny shows that CD4 T cell memory and lymph nodes coevolved in placental mammals. In ontogeny, retinoic acid orphan receptor (ROR)γ-dependent lymphoid tissue inducer (LTi) cells program the development of mammalian lymph nodes. In this study, we show that although primary CD4 T cell expansion is normal in RORγ-deficient mice, the persistence of memory CD4 T cells is RORγ-dependent. Furthermore, using bone marrow chimeric mice we demonstrate that LTi cells are the key RORγ-expressing cell type sufficient for memory CD4 T cell survival in the absence of persistent Ag. This effect was specific for CD4 T cells, as memory CD8 T cells survived equally well in the presence or absence of LTi cells. These data demonstrate a novel role for LTi cells, archetypal members of the innate lymphoid cell family, in supporting memory CD4 T cell survival in vivo. |
| Databáze: | OpenAIRE |
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