Differentiated effects of deep brain stimulation and medication on somatosensory processing in Parkinson's disease
| Autor: | Lars Gottfried Johansen, Sunde Na, Kousik Sarathy Sridharan, Andreas Højlund, Karen Østergaard, Sándor Beniczky, E. L. Johnsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Somatosensory processing Parkinson's disease Deep brain stimulation Deep Brain Stimulation medicine.medical_treatment Disease Somatosensory system 050105 experimental psychology Antiparkinson Agents 03 medical and health sciences 0302 clinical medicine Evoked Potentials Somatosensory Physiology (medical) Journal Article medicine Humans 0501 psychology and cognitive sciences Sensory symptoms medicine.diagnostic_test Median nerve stimulation business.industry 05 social sciences Dopaminergic Magnetoencephalography Parkinson Disease Somatosensory Cortex Middle Aged medicine.disease Sensory Systems Neurology Anesthesia Female Neurology (clinical) Induced gamma augmentation business 030217 neurology & neurosurgery |
| Zdroj: | Sridharan, K S, Højlund, A, Johnsen, E L, Sunde, N A, Johansen, L G, Beniczky, S & Østergaard, K 2017, ' Differentiated effects of deep brain stimulation and medication on somatosensory processing in Parkinson's disease ', Clinical Neurophysiology, vol. 128, no. 7, pp. 1327-1336 . https://doi.org/10.1016/j.clinph.2017.04.014 Sridharan, K S, Højlund, A, Johnsen, E L, Sunde, N, Johansen, L G, Beniczky, S & Østergaard, K 2017, ' Differentiated effects of deep brain stimulation and medication on somatosensory processing in Parkinson's disease ', Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, vol. 128, no. 7, pp. 1327-1336 . https://doi.org/10.1016/j.clinph.2017.04.014 |
| DOI: | 10.1016/j.clinph.2017.04.014 |
| Popis: | OBJECTIVES: Deep brain stimulation (DBS) and dopaminergic medication effectively alleviate the motor symptoms in Parkinson's disease (PD) patients, but their effects on the sensory symptoms of PD are still not well understood. To explore early somatosensory processing in PD, we recorded magnetoencephalography (MEG) from thirteen DBS-treated PD patients and ten healthy controls during median nerve stimulation.METHODS: PD patients were measured during DBS-treated, untreated and dopaminergic-medicated states. We focused on early cortical somatosensory processing as indexed by N20m, induced gamma augmentation (31-45Hz and 55-100Hz) and induced beta suppression (13-30Hz). PD patients' motor symptoms were assessed by UPDRS-III.RESULTS: Using Bayesian statistics, we found positive evidence for differentiated effects of treatments on the induced gamma augmentation (31-45Hz) with highest gamma in the dopaminergic-medicated state and lowest in the DBS-treated and untreated states. In contrast, UPDRS-III scores showed beneficial effects of both DBS and dopaminergic medication on the patients' motor symptoms. Furthermore, treatments did not affect the amplitude of N20m.CONCLUSIONS: Our results suggest differentiated effects of DBS and dopaminergic medication on cortical somatosensory processing in PD patients despite consistent ameliorating effects of both treatments on PD motor symptoms.SIGNIFICANCE: The differentiated effect suggests differences in the effect mechanisms of the two treatments. |
| Databáze: | OpenAIRE |
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