Disability after encephalitis: development and validation of a new outcome score
| Autor: | See Chang Wong, Rachel Kneen, M. Veera Shankar, Gaurav Mandhan, Indunil Sandaradura, Anand Mohan, Srihari Penkulinti, Asma Begum, Mong How Ooi, Boon Foo Lai, R. Ravikumar, Ashia Begum, Vydianathan Ravi, Carolyn A Young, Pratibha Meharwade, Mary Jane Cardosa, Tom Solomon, Penny Lewthwaite, S Subhashini, Brian Faragher, Gulia Abhishek |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Adolescent India Pilot Projects Test validity Severity of Illness Index Disability Evaluation Surveys and Questionnaires Positive predicative value Severity of illness medicine Humans Disabled Persons Child business.industry Research Public health Malaysia Public Health Environmental and Occupational Health Japanese encephalitis medicine.disease El Niño Child Preschool Etiology Encephalitis Female business |
| Zdroj: | Bulletin of the World Health Organization. 88:584-592 |
| ISSN: | 0042-9686 |
| Popis: | OBJECTIVE: To develop a simple tool for assessing the severity of disability resulting from Japanese encephalitis and whether, as a result, a child is likely to be dependent. METHODS: A new outcome score based on a 15-item questionnaire was developed after a literature review, examination of current assessment tools, discussion with experts and a pilot study. The score was used to evaluate 100 children in Malaysia (56 Japanese encephalitis patients, 2 patients with encephalitis of unknown etiology and 42 controls) and 95 in India (36 Japanese encephalitis patients, 41 patients with encephalitis of unknown etiology and 18 controls). Inter- and intra-observer variability in the outcome score was determined and the score was compared with full clinical assessment. FINDINGS: There was good inter-observer agreement on using the new score to identify likely dependency (K = 0.942 for Malaysian children; K = 0.786 for Indian children) and good intra-observer agreement (K = 1.000 and 0.902, respectively). In addition, agreement between the new score and clinical assessment was also good (K = 0.906 and 0.762, respectively). The sensitivity and specificity of the new score for identifying children likely to be dependent were 100% and 98.4% in Malaysia and 100% and 93.8% in India. Positive and negative predictive values were 84.2% and 100% in Malaysia and 65.6% and 100% in India. CONCLUSION: The new tool for assessing disability in children after Japanese encephalitis was simple to use and scores correlated well with clinical assessment. |
| Databáze: | OpenAIRE |
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