Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin

Autor:	James F. Sanchez, Chun-Jun Guo, Hsien-Chun Lo, Berl R. Oakley, Clay C. C. Wang, Kenneth S. Bruno, Yi-Ming Chiang, Benjamin P. Knox, Kuan-Han Lee
Rok vydání:	2012
Předmět:	Molecular Structure Terpenes Chemistry Extramural Organic Chemistry Mutant bacterial infections and mycoses Biochemistry Aspergillus nidulans Article Terpenoid Polyketide chemistry.chemical_compound Biosynthesis Physical and Theoretical Chemistry skin and connective tissue diseases Gene
Zdroj:	Organic Letters. 14:5684-5687
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol302682z
Popis:	Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395328af2aaa590fb4b5ce8482a00767 https://doi.org/10.1021/ol302682z Zobrazit plný text záznamu