Anxiolytic and sedative-hypnotic activities of polygalasaponins fromPolygala tenuifoliain mice

Autor:	Lian-Na Sun, Min Jia, Jian-Guo Wu, Khalid Rahman, Hong Zhang, Wan-Sheng Chen, Yi Yao
Rok vydání:	2010
Předmět:	Male Elevated plus maze Polygala medicine.drug_class Drug Evaluation Preclinical Pharmaceutical Science Motor Activity Pharmacology Anxiolytic Median lethal dose Open field Lethal Dose 50 Mice Drug Discovery Sedative/hypnotic medicine Animals Hypnotics and Sedatives Maze Learning Mice Knockout biology Plant Extracts business.industry Lethal dose Immobility Response Tonic General Medicine Saponins biology.organism_classification Anti-Anxiety Agents Complementary and alternative medicine Polygala tenuifolia Molecular Medicine Diterpenes Kaurane business Phytotherapy
Zdroj:	Pharmaceutical Biology. 48:801-807
ISSN:	1744-5116 1388-0209
Popis:	In the present study, the anxiolytic and sedative-hypnotic activities of polygalasaponins extracted from Polygala tenuifolia Willdenow (Polygalaceae) were determined in mice using hole-board, elevated plus maze, open field, and sodium pentobarbital-induced hypnosis tests. Moreover, the acute toxicity of polygalasaponins was also estimated in mice. Sixty minutes after p.o. administration of polygalasaponins (40, 80, 160 mg/kg) in mice, the central crossing counts and percentage of central/total ambulation significantly increased and the number of rearings and defecations was evidently inhibited in the open field test. Polygalasaponins also increased the head-dips of mice in the hole-board test and the time spent by mice in the open arms of the X-maze, prolonged sleep duration and shortened sleep latency in the test of synergetic effect on sodium pentobarbital (45 and 25 mg/kg, respectively). Acute toxic study showed the oral median lethal dose (LD(50)) of polygalasaponins was 3.95 g/kg and 0% lethal dose 2.6 g/kg. These results suggest that polygalasaponin possesses evident anxiolytic and sedative-hypnotic activities and has a relatively safe dose range, which supports the use of Polygala tenuifolia root as an anxiolytic and sedative-hypnotic drug in folk medicine.
Databáze:	OpenAIRE
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