Reduced trabecular bone mineral density and cortical thickness accompanied by increased outer bone circumference in metacarpal bone of rheumatoid arthritis patients: a cross-sectional study
| Autor: | Harald M. Bonel, Gion Caliezi, Daniel Aeberli, Peter M. Villiger, Jolanda Widmer, Pierre-Alain Varisco, Prisca Eser, Burkhard Möller |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
musculoskeletal diseases medicine.medical_specialty Immunology Arthritis Arthritis Rheumatoid Rheumatology Bone Density Internal medicine medicine Humans Immunology and Allergy Tibia Quantitative computed tomography Aged medicine.diagnostic_test business.industry Reproducibility of Results Anatomy Metacarpal Bones Middle Aged musculoskeletal system medicine.disease Radius medicine.anatomical_structure Epiphysis Case-Control Studies Rheumatoid arthritis Orthopedic surgery Third metacarpal bone Female Tomography X-Ray Computed business Epiphyses Research Article |
| Zdroj: | Aeberli, Daniel; Eser, Prisca; Bonel, Harald; Widmer, Jolanda; Caliezi, Gion; Varisco, Pierre-Alain; Möller, Burkhard; Villiger, Peter M (2010). Reduced trabecular bone mineral density and cortical thickness accompanied by increased outer bone circumference in metacarpal bone of rheumatoid arthritis patients: a cross-sectional study. Arthritis research & therapy, 12(3), R119. London: BioMed Central 10.1186/ar3056 Arthritis Research & Therapy |
| ISSN: | 1478-6354 |
| Popis: | Introduction The objective of this study was to assess three-dimensional bone geometry and density at the epiphysis and shaft of the third meta-carpal bone of rheumatoid arthritis (RA) patients in comparison to healthy controls with the novel method of peripheral quantitative computed tomography (pQCT). Methods PQCT scans were performed in 50 female RA patients and 100 healthy female controls at the distal epiphyses and shafts of the third metacarpal bone, the radius and the tibia. Reproducibility was determined by coefficient of varia-tion. Bone densitometric and geometric parameters were compared between the two groups and correlated to disease characteristics. Results Reproducibility of different pQCT parameters was between 0.7% and 2.5%. RA patients had 12% to 19% lower trabecular bone mineral density (BMD) (P ≤ 0.001) at the distal epiphyses of radius, tibia and metacarpal bone. At the shafts of these bones RA patients had 7% to 16% thinner cortices (P ≤ 0.03). Total cross-sectional area (CSA) at the metacarpal bone shaft of pa-tients was larger (between 5% and 7%, P < 0.02), and relative cortical area was reduced by 13%. Erosiveness by Ratingen score correlated negatively with tra-becular and total BMD at the epiphyses and shaft cortical thickness of all measured bones (P < 0.04). Conclusions Reduced trabecular BMD and thinner cortices at peripheral bones, and a greater bone shaft diameter at the metacarpal bone suggest RA spe-cific bone alterations. The proposed pQCT protocol is reliable and allows measuring juxta-articular trabecular BMD and shaft geometry at the metacarpal bone. |
| Databáze: | OpenAIRE |
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