The added value of digital imaging to reflex cytology for triage of high-risk human papillomavirus positive self-sampled material in cervical cancer screening: A prospective cohort study
| Autor: | Danique Wiersma, Anne Vinke, Albert G. Siebers, Willem J. G. Melchers, Ruud L. M. Bekkers, Diede L. Loopik |
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| Přispěvatelé: | Obstetrie & Gynaecologie, RS: GROW - R2 - Basic and Translational Cancer Biology |
| Rok vydání: | 2023 |
| Předmět: |
Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17]
Papillomavirus Infections Obstetrics and Gynecology Uterine Cervical Neoplasms Alphapapillomavirus Uterine Cervical Dysplasia Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] All institutes and research themes of the Radboud University Medical Center Pregnancy Colposcopy Reflex Humans Female Prospective Studies Triage Papillomaviridae Early Detection of Cancer |
| Zdroj: | BJOG : an International Journal of Obstetrics and Gynaecology, 130, 184-191 Bjog-an International Journal of Obstetrics and Gynaecology, 130(2), 184-191. Wiley BJOG : an International Journal of Obstetrics and Gynaecology, 130, 2, pp. 184-191 |
| ISSN: | 1470-0328 |
| Popis: | Contains fulltext : 291088.pdf (Publisher’s version ) (Open Access) OBJECTIVE: Cytology performed directly on hrHPV-positive self-samples (reflex cytology) is feasible and for women with abnormal cytology, an additional cytology test at the general practitioner could be omitted. The aim of this study is to assess the added value of digital imaging (ThinPrep® Imaging System) on the clinical utility of reflex cytology by reducing screening error. DESIGN: A secondary analysis of a prospective cohort study. SETTING: One of five Dutch screening laboratories. POPULATION: Women tested hrHPV-positive on self-samples between December 2018 and August 2019. METHODS: Self-samples were used for reflex cytology with and without digital imaging. The follow-up data (cytological and histological results within 1 year of follow-up) were obtained through the Dutch Pathology Registry (PALGA). MAIN OUTCOME MEASURES: Test performance of the reflex cytology was determined by comparing it with physician-collected follow-up results. RESULTS: The sensitivity for detecting abnormal cells by reflex cytology on self-samples increased significantly from 26.3% (42/160; 95% confidence interval [CI] 19.6-33.8) without digital imaging to 35.4% (56/158; 95% CI 28-43.4) with digital imaging (P |
| Databáze: | OpenAIRE |
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