Electrical stimulation of the endopiriform nucleus attenuates epilepsy in rats by network modulation
| Autor: | Horace H Loh, Wei Wang, Xiaofeng Yang, Milin Zhang, Yue Xing, Zhiyi Sha, Thomas R. Henry, Jiaqing Yan, Donghong Li, Junling Wang, Zhangyi Yuan, Deng Luo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Deep brain stimulation medicine.medical_treatment Deep Brain Stimulation Hippocampus Stimulation Electric Stimulation Therapy Piriform Cortex Electroencephalography Rats Sprague-Dawley 03 medical and health sciences Epilepsy 0302 clinical medicine Seizures medicine Animals Ictal Theta Rhythm CA1 Region Hippocampal Research Articles medicine.diagnostic_test business.industry General Neuroscience Motor Cortex medicine.disease Rats Disease Models Animal 030104 developmental biology medicine.anatomical_structure Implantable Neurostimulators Anesthesia Neurology (clinical) Electrocorticography business Nucleus 030217 neurology & neurosurgery Motor cortex Research Article |
| Zdroj: | Annals of Clinical and Translational Neurology |
| ISSN: | 2328-9503 |
| Popis: | Objective Neuromodulatory anterior thalamic deep brain stimulation (DBS) is an effective therapy for intractable epilepsy, but few patients achieve complete seizure control with thalamic DBS. Other stimulation sites may be considered for anti‐seizure DBS. We investigated bilateral low‐frequency stimulation of the endopiriform nuclei (LFS‐EPN) to control seizures induced by intracortically implanted cobalt wire in rats. Methods Chronic epilepsy was induced by cobalt wire implantation in the motor cortex unilaterally. Bipolar‐stimulating electrodes were implanted into the EPN bilaterally. Continuous electroencephalography (EEG) was recorded using electrodes placed into bilateral motor cortex and hippocampus CA1 areas. Spontaneous seizures were monitored by long‐term video‐EEG, and behavioral seizures were classified based on the Racine scale. Continuous 1‐Hz LFS‐EPN began on the third day after electrode implantation and was controlled by a multi‐channel stimulator. Stimulation continued until the rats had no seizures for three consecutive days. Results Compared with the control and sham stimulation groups, the LFS‐EPN group experienced significantly fewer seizures per day and the mean Racine score of seizures was lower due to fewer generalized seizures. Ictal discharges at the epileptogenic site had significantly reduced theta band power in the LFS‐EPN group compared to the other groups. Interpretation Bilateral LFS‐EPN attenuates cobalt wire‐induced seizures in rats by modulating epileptic networks. Reduced ictal theta power of the EEG broadband spectrum at the lesion site may be associated with the anti‐epileptogenic mechanism of LFS‐EPN. Bilateral EPN DBS may have therapeutic applications in human partial epilepsies. |
| Databáze: | OpenAIRE |
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