Multiple Deeply Divergent Denisovan Ancestries in Papuans
Autor: | Luca Pagani, Mayukh Mondal, Murray P. Cox, Lauri Saag, Daniel Lawson, Mark Stoneking, Guy S. Jacobs, Chelzie Crenna Darusallam, Georgi Hudjashov, François-Xavier Ricaut, J. Stephen Lansing, Pradiptajati Kusuma, Mait Metspalu, Herawati Sudoyo |
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Přispěvatelé: | Jacobs, Guy Sherwin [0000-0002-4698-7758], Apollo - University of Cambridge Repository, Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Human Genetics, Evolutionary Genetics, University of Tartu, Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées |
Rok vydání: | 2019 |
Předmět: |
Gene Flow
Neanderthal Pleistocene Lineage (evolution) [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology Oceania Introgression Wallace Line Genetic Introgression Genome archaic ancestry General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Asian People biology.animal Denisovan Animals Humans 030304 developmental biology Neanderthals 0303 health sciences New Guinea biology Genome Human Haplotype Genetic Variation Hominidae biology.organism_classification Biological Evolution Haplotypes Evolutionary biology Indonesia Island Southeast Asia 030217 neurology & neurosurgery |
Zdroj: | Cell Cell, Elsevier, 2019, ⟨10.1016/j.cell.2019.02.035⟩ Jacobs, G, Hudjashov, G, Saag, L, Kusuma, P, Darusallam, C C, Lawson, D, Mondal, M, Pagani, L, Ricaut, F-X, Stoneking, M, Metspalu, M, Sudoyu, H, Lansing, J S & Cox, M P 2019, ' Multiple Deeply Divergent Denisovan Ancestries in Papuans ', Cell, vol. 177, no. 4, pp. 1010-1021.e32 . https://doi.org/10.1016/j.cell.2019.02.035 |
ISSN: | 0092-8674 1097-4172 |
Popis: | International audience; Genome sequences are known for two archaic hominins-Neanderthals and Denisovans-which interbred with anatomically modern humans as they dispersed out of Africa. We identified high-confidence archaic haplotypes in 161 new genomes spanning 14 island groups in Island Southeast Asia and New Guinea and found large stretches of DNA that are inconsistent with a single introgressing Denisovan origin. Instead, modern Papuans carry hundreds of gene variants from two deeply divergent Denisovan lineages that separated over 350 thousand years ago. Spatial and temporal structure among these lineages suggest that introgression from one of these Denisovan groups predominantly took place east of the Wallace line and continued until near the end of the Pleistocene. A third Denisovan lineage occurs in modern East Asians. This regional mosaic suggests considerable complexity in archaic contact, with modern humans interbreeding with multiple Denisovan groups that were geographically isolated from each other over deep evolutionary time. |
Databáze: | OpenAIRE |
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