Association between left ventricular hypertrophy and changes in arterial stiffness during hypertensive treatment
| Autor: | Takashi Himoto, Hiroki Okada, Naohisa Hosomi, Michio Inukai, Fuminori Goda, Hisashi Masugata, Shoichi Senda, Koji Murao |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Blood Pressure Angiotensin II Receptor Blockers Left ventricular hypertrophy Left ventricular mass Vascular Stiffness Internal medicine Internal Medicine medicine Humans Ankle Brachial Index Cardio-ankle vascular index Aged Retrospective Studies Aged 80 and over business.industry General Medicine Middle Aged Prognosis medicine.disease Blood pressure Echocardiography Hypertension Disease Progression Arterial stiffness Cardiology Female Hypertrophy Left Ventricular business Follow-Up Studies |
| Zdroj: | Clinical and Experimental Hypertension. 36:258-262 |
| ISSN: | 1525-6006 1064-1963 |
| Popis: | Cardio-ankle vascular index (CAVI) has been demonstrated as a parameter of arterial stiffness, which antihypertensive therapy may improve. However, little information is available about the factors affecting changes in arterial stiffness assessed by CAVI during antihypertensive therapy. We performed a study to examine the factors affecting changes in arterial stiffness assessed by CAVI during antihypertensive therapy. Eighty treated hypertensive patients (71 ± 10 years) were divided into two groups: 50 patients showing a decrease in CAVI (Group 1) and 30 patients showing an increase (Group 2) during observation (24 ± 11 months) of antihypertensive therapy. The groups did not differ in the rates of use of angiotensin II receptor blockers or calcium channel blockers. Age (Group 1: 67 ± 11 versus Group 2: 74 ± 8 years), left ventricular mass index (LVMI) (Group 1: 103 ± 19 versus Group 2: 120 ± 24 g/m(2)) and systolic blood pressure (Group 1: 133 ± 17 versus Group 2: 144 ± 23 mm Hg) at the start of observation were significantly higher in Group 2 than in Group 1 (p = 0.003, p = 0.001 and p = 0.027, respectively). The changes in CAVI during observation were correlated only with LVMI (r = 0.289, p = 0.009) at the start of observation for all 80 patients. It may be difficult to improve arterial stiffness assessed by CAVI during antihypertensive therapy in hypertensive patients with left ventricular hypertrophy. |
| Databáze: | OpenAIRE |
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