Nephrotoxicity of Herbal Medicine and Its Prevention
| Autor: | Ruyi Zhu, Xin Wu, Xiaofen Xu, Mengting Zhao, Gang Cao, Kuilong Wang, Jialiang Ying |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
prevention strategies Review Pharmacology toxic components Aristolochia Nephrotoxicity 03 medical and health sciences 0302 clinical medicine Renal injury Renal fibrosis Medicine Pharmacology (medical) Artemisinin Adverse effect biology business.industry nephrotoxicity lcsh:RM1-950 biology.organism_classification toxicity mechanism lcsh:Therapeutics. Pharmacology 030104 developmental biology 030220 oncology & carcinogenesis Toxicity herbal medicine business medicine.drug |
| Zdroj: | Frontiers in Pharmacology Frontiers in Pharmacology, Vol 11 (2020) |
| ISSN: | 1663-9812 |
| Popis: | Herbal medicine (HM) has been widely used to treat diseases for thousands of years and has greatly contributed to the health of human beings. Many new drugs have been developed from HM, such as artemisinin. However, artemisinin has adverse effects, such as renal toxicity. In 1993, a study conducted in Belgium reported for the first time that the root extracts of Aristolochia obliqua S. M. Hwang led to progressive interstitial renal fibrosis. The nephrotoxicity of HM has attracted worldwide attention. More than 100 kinds of HM induce renal toxicity, including some herbs, animal HMs, and minerals. This paper aimed to summarize the HM compounds that cause nephrotoxicity, the mechanisms underlying the toxicity of these compounds, biomarkers of renal injury, and prevention strategies. These findings provide a basis for follow-up studies on the prevention and treatment of HM nephrotoxicity. |
| Databáze: | OpenAIRE |
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