Extracellular fluid volume and glomerular filtration rate in 1878 healthy potential renal transplant donors: effects of age, gender, obesity and scaling
| Autor: | Mark C. Barnfield, Richard S. Lawson, Hayley Snelling, Bethany Howard, Mark D. J. Neilly, Gregory Shabo, Thomas Grüning, Surendra Dave, Ravin Sobnack, Neva H. Patel, Andrew Irwin, A. Michael Peters, Nigel Williams, Laura Perry, Nagabhushan Seshadri, Claire A. Hooker |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Urology Renal function Kidney Function Tests urologic and male genital diseases Body Mass Index Sex Factors Internal medicine Extracellular fluid medicine Humans Obesity Prospective Studies Radionuclide Imaging reproductive and urinary physiology Aged Retrospective Studies Body surface area Transplantation urogenital system business.industry Age Factors Extracellular Fluid Middle Aged Prognosis medicine.disease Kidney Transplantation Chromium Radioisotopes Tissue Donors female genital diseases and pregnancy complications Endocrinology Nephrology Renal transplant External cephalic version Lean body mass Female business Body mass index Follow-Up Studies Glomerular Filtration Rate |
| Zdroj: | Nephrology Dialysis Transplantation. 27:1429-1437 |
| ISSN: | 1460-2385 0931-0509 |
| Popis: | Aim. The aim of this study was to investigate the influence of age, gender, obesity and scaling on glomerular filtration rate (GFR) and extracellular fluid volume (ECV) in healthy subjects.This is a retrospective multi-centre study of 1878 healthy prospective kidney transplant donors (819 men) from 15 centres. Age and body mass index (BMI) were not significantly different between men and women. Slope-intercept GFR was measured (using Cr-51-EDTA in 14 centres; Tc-99m-DTPA in one) and scaled to body surface area (BSA) and lean body mass (LBM), both estimated from height and weight. GFR was also expressed as the slope rate constant, with one-compartment correction (GFR/ECV). ECV was measured as the ratio, GFR to GFR/ECV.ECV was age independent but GFR declined with age, at a significantly faster rate in women than men. GFR/BSA was higher in men but GFR/ECV and GFR/LBM were higher in women. Young women (30 years) had higher GFR than young men but the reverse was recorded in the elderly (65 years). There was no difference in GFR between obese (BMI30 kg/m2) and non-obese men. Obese women, however, had lower GFR than non-obese women and negative correlations were observed between GFR and both BMI and %fat. The decline in GFR with age was no faster in obese versus non-obese subjects. ECV/BSA was higher in men but ECV/LBM was higher in women. ECV/weight was almost gender independent, suggesting that fat-free mass in women contains more extracellular water. BSA is therefore a misleading scaling variable.There are several significant differences in GFR and ECV between healthy men and women. |
| Databáze: | OpenAIRE |
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