| Autor: |
Tatyana A. Grigoreva, Aleksandra V. Sagaidak, Daria S. Novikova, Vyacheslav G. Tribulovich |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
European Journal of Pharmacology. 935:175327 |
| ISSN: |
0014-2999 |
| DOI: |
10.1016/j.ejphar.2022.175327 |
| Popis: |
ABC transporters play an essential role in the development of multidrug resistance and thus are of interest in the context of anticancer therapy. However, MDR1, BCRP and MRP1 are involved in a number of key processes that maintain the viability of the body as a whole, as well as individual organs and cells. These transporters support protective properties of anatomical and histohematic barriers, determining the entry of both toxins and drugs into organs and tissues, as well as facilitating their elimination. This review discusses the main areas in which the use of modulators of the ABC exporter activity may be relevant due to either an initial imbalance in their activity or the need for the temporary change in the efflux rate for therapeutic purposes. Controlled modulation of the activity of the ABC family efflux transporters opens up broad prospects in the treatment of various diseases associated both with universal difficulties in the delivery of drugs that are transporter substrates and with the characteristics of individual patients caused by single nucleotide polymorphisms. Both activators and inhibitors of the transporters will find their application. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect