Seroprotection against serogroup C meningococcal disease in adolescents in the United Kingdom: observational study
| Autor: | C. Nau, Ray Borrow, Catrin E. Moore, L. Kibwana, Andrew J. Pollard, Tessa M. John, Ly-Mee Yu, Astrid Borkowski, Matthew D. Snape, Susan Lewis, Linda Diggle, C. Banner, Dominic F. Kelly |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Immunology Meningococcal Vaccines Meningococcal vaccine Neisseria meningitidis Serogroup C Meningitis Meningococcal Meningococcal disease Herd immunity Age Distribution medicine Humans Meningitis Child General Environmental Science biology business.industry Research General Engineering Paediatrics General Medicine medicine.disease Antibodies Bacterial Confidence interval United Kingdom Titer Cohort biology.protein General Earth and Planetary Sciences Regression Analysis Observational study Female sense organs Antibody business Biomarkers |
| Popis: | Objective To determine the persistence of bactericidal antibody titres following immunisation with serogroup C meningococcal glycoconjugate vaccine at age 6-15 years in order to examine changes in persistence of antibodies with age. Design Observational study. Setting Secondary and tertiary educational institutions in the United Kingdom. Participants Healthy adolescents aged 11-20 years previously immunised between 6 and 15 years of age with one of the three serogroup C meningococcal vaccines. Intervention Serum obtained by venepuncture. Main outcome measures Percentage of participants with (rabbit complement) serum bactericidal antibody titres of at least 1:8; geometric mean titres of serogroup C meningococcal serum bactericidal antibody. Results Five years after immunisation, 84.1% (95% confidence interval 81.6% to 86.3%) of 987 participants had a bactericidal antibody titre of at least 1:8. Geometric mean titres of bactericidal antibody were significantly lower in 11-13 year olds (147, 95% confidence interval 115 to 188) than in 14-16 year olds (300, 237 to 380) and 17-20 year olds (360, 252 to 515) (P |
| Databáze: | OpenAIRE |
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