Increased Potassium Permeability in Erythrocytes from Patients with Hyperparathyroidism
Autor: | B. Lacour, M. Price, J. Fernandez, T. Drüeke, R. P. Garay, J. Diez, J. D. Monet |
---|---|
Rok vydání: | 1986 |
Předmět: |
Adult
Male Parathyroidectomy medicine.medical_specialty Cell Membrane Permeability Erythrocytes Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Parathyroid hormone Biochemistry Ion Channels Parathyroid Glands Blood cell Endocrinology In vivo Internal medicine medicine Humans Aged Hyperparathyroidism Quinine Chemistry Sodium Biochemistry (medical) General Medicine Middle Aged medicine.disease Red blood cell medicine.anatomical_structure Parathyroid Hormone Potassium Female Secondary hyperparathyroidism Ex vivo |
Zdroj: | Europe PubMed Central |
ISSN: | 1439-4286 0018-5043 |
DOI: | 10.1055/s-2007-1012394 |
Popis: | Parathyroid hormone (PTH) has been shown to modify Ca2+ and Na+ transport in several epithelia. The molecular mechanisms of these effects are poorly understood. We investigated here whether PTH may modify Na+ and K+ transport across the human red blood cell membrane in vitro and ex vivo. Fourteen patients with severe primary or secondary hyperparathyroidism and hypercalcemia were studied before and 5-7 days after surgical parathyroidectomy. Erythrocyte ouabain-sensitive as well as furosemide-sensitive Na+ efflux rates of the patients were comparable to that of healthy volunteers and remained unchanged after parathyroidectomy. Moreover, erythrocyte Na+ fluxes of control subjects remained unchanged when red blood cells were incubated in the presence of 1.0 IU/ml of bovine PTH (1-85). However, erythrocytes from hyperparathyroid patients showed a significant increase in passive K+ permeability when compared to that of healthy controls (p less than 0.05). This abnormality could be corrected in vivo after parathyroidectomy and in vitro using quinine, respectively. It is concluded that hyperparathyroidism induces a moderate increase in Ca2+ dependent K+ permeability of erythrocytes ("Gardos effect") which is reversible after parathyroidectomy. |
Databáze: | OpenAIRE |
Externí odkaz: |