Defining the target value of the coefficient of variation by continuous glucose monitoring in Chinese people with diabetes
| Autor: | Yuqian Bao, Wei Lu, Jingyi Lu, Jian Zhou, Lei Zhang, Wei Zhu, Xiaojing Ma, Yifei Mo, Yun Shen, Yufei Wang |
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| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male Percentile Endocrinology Diabetes and Metabolism medicine.medical_treatment 030204 cardiovascular system & hematology Gastroenterology chemistry.chemical_compound 0302 clinical medicine Reference Values Insulin Medicine Glycemic variability Continuous glucose monitoring Articles General Medicine Middle Aged Clinical Science and Care Female Original Article China medicine.medical_specialty Coefficient of variation 030209 endocrinology & metabolism Glycemic Control Hypoglycemia Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences Asian People Diabetes mellitus Internal medicine Internal Medicine Humans Hypoglycemic Agents Aged Retrospective Studies Glycemic Glycated Hemoglobin Receiver operating characteristic business.industry Blood Glucose Self-Monitoring RC648-665 medicine.disease Diabetes Mellitus Type 1 Diabetes Mellitus Type 2 ROC Curve chemistry Glycated hemoglobin business |
| Zdroj: | Journal of Diabetes Investigation, Vol 12, Iss 6, Pp 1025-1034 (2021) Journal of Diabetes Investigation |
| ISSN: | 2040-1124 2040-1116 |
| Popis: | Aims/Introduction To define the target value for the percentage coefficient of variation for glucose (%CV) as a measure of glycemic variability (GV) in Chinese diabetes patients. Materials and Methods This retrospective study included 3,007 diabetes patients who underwent continuous glucose monitoring for 3 days. Type 2 diabetes was divided into groups according to the received treatment: group 1, non‐insulinotropic agent (n = 138); group 2, insulinotropic agent (n = 761); group 3, basal insulin therapy (n = 100); group 4, premixed insulin (n = 784); and group 5, intensive insulin therapy (n = 612). Type 1 diabetes patients were included as group 6 (n = 612). %CV and percentage of time per day within, below (3.9mmol/L; TBR3.9) and above (10.0 mmol/L) the target glucose range (3.9–10.0 mmol/L) were computed. TBR3.9 ≥4% was defined as excessive hypoglycemia. Results Type 2 diabetes with a premixed or intensive insulin regimen had an increased %CV compared with those receiving oral therapy or basal insulin. The upper limit of %CV in group 1 was 33%, which was adopted as the threshold to define excessive GV. For each treatment group, the percentage of people with TBR3.9 ≥4% was significantly greater in the subgroup with %CV >33% than ≤33% (P 70% and time per day above 10.0 mmol/L |
| Databáze: | OpenAIRE |
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