Silver-Catalyzed Decarboxylative Bromination of Aliphatic Carboxylic Acids

Autor:	Lei Cui, Chaozhong Li, Zhentao Wang, Xinqiang Tan, He Chen, Tao Song
Rok vydání:	2017
Předmět:	chemistry.chemical_classification 010405 organic chemistry Organic Chemistry Halogenation 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Catalysis chemistry Organic chemistry Dibromoisocyanuric acid Physical and Theoretical Chemistry Alkyl
Zdroj:	Organic Letters. 19:1634-1637
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.7b00439
Popis:	The silver-catalyzed Hunsdiecker bromination of aliphatic carboxylic acids is described. With Ag(Phen)2OTf as the catalyst and dibromoisocyanuric acid as the brominating agent, various aliphatic carboxylic acids underwent decarboxylative bromination to provide the corresponding alkyl bromides under mild conditions. This method not only is efficient and general but also enjoys wide functional group compatibility. An oxidative radical mechanism involving Ag(II) intermediates is proposed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393c57b433124920c6be0427b490742f https://doi.org/10.1021/acs.orglett.7b00439 Zobrazit plný text záznamu