Prognostic Significance Of Platelet-To-Lymphocyte Ratio (PLR) And Mean Platelet Volume (MPV) During Etoposide-Based First-Line Treatment In Small Cell Lung Cancer Patients
| Autor: | Benjie Shan, Lin Lin, Wei Wang, Xia-Bo Shen, Liu Yu, Yueyin Pan, Wang Yong, Li Hao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Multivariate analysis Lymphocyte medicine.medical_treatment PLR Gastroenterology MPV 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Platelet Mean platelet volume Lung cancer Etoposide Original Research Chemotherapy mean platelet volume business.industry Proportional hazards model SCLC prediction medicine.disease platelet-to-lymphocyte ratio body regions first-line chemotherapy 030104 developmental biology medicine.anatomical_structure Oncology Cancer Management and Research 030220 oncology & carcinogenesis small cell lung cancer business medicine.drug |
| Zdroj: | Cancer Management and Research |
| ISSN: | 1179-1322 |
| Popis: | Xia-Bo Shen,1,2,* Yong Wang,2,* Ben-Jie Shan,2 Lin Lin,2 Li Hao,2 Yu Liu,1,2 Wei Wang,2 Yue-Yin Pan1,2 1Department of Medical Oncology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, People’s Republic of China; 2Department of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yue-Yin PanDepartment of Medical Oncology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, People’s Republic of ChinaEmail yueyinpan1965@163.comWei WangDepartment of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, People’s Republic of ChinaEmail docweiwang@fsyy.ustc.edu.cnBackground: Small cell lung cancer (SCLC) is a special type of lung cancer and it is responsive to chemotherapy. Blood parameters have been proved to be associated with survival for many types of malignancies. This study aimed to investigate the prognostic significance of platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) for SCLC patients with etoposide-based first-line treatment.Methods: We retrospectively identified 138 patients diagnosed as SCLC who underwent etoposide-based first-line chemotherapy. The patients’ baseline clinical characteristics and blood parameters were collected. Kaplan–Meier analysis and Cox regression methods were used to determine the factors associated with progression-free survival (PFS).Results: The optimal cut-off value of diagnosis was depended on the ROC curve, the cut-off value of pretreatment PLR was 190 (sensitivity 39.0%, specificity 88.5%), and the cut-off value of pretreatment MPV was 10.0 (sensitivity 60.7%, specificity 61%). Kaplan–Meier analysis showed patients with high PLR levels in baseline had worse PFS than those with low PLR levels (P |
| Databáze: | OpenAIRE |
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