Uric Acid Metabolism in Patients with Primary Gout and the Metabolic Syndrome

Autor:	J. M. Fraile, Pedro A. Martínez, Eugenio de Miguel, Juan G. Puig, J. J. Vázquez, Rosa J. Torres
Rok vydání:	2010
Předmět:	Male medicine.medical_specialty Gout Urinary system Biochemistry chemistry.chemical_compound Internal medicine Genetics medicine Humans In patient Hyperuricemia Metabolic Syndrome Creatinine General Medicine Metabolism Middle Aged medicine.disease Uric Acid Endocrinology chemistry Molecular Medicine Uric acid Female Metabolic syndrome
Zdroj:	Nucleosides, Nucleotides and Nucleic Acids. 29:330-334
ISSN:	1532-2335 1525-7770
Popis:	Forty-four patients (40 males) with a mean age of 58 years were included in this pilot study. Mean serum urate concentration in patients with and without the metabolic syndrome (MS) was 8.8 mg/dL and 8.1 mg/dL, respectively. Urinary uric acid excretion was 543 mg/day/1.73 m(2) in the former and 609 mg/day/1.73 m(2) in the latter. Uric acid to creatinine ratio was 0.37 mg/mg in patients with the MS and 0.42 mg/mg in those without the MS. Mean serum urate increased from 8.6 mg/dL in subjects with three or more MS components to 10.3 mg/dL in those with five MS components. Serum urate was markedly lower in patients with mild MS (9 patients, 8.6 mg/dL) as compared to severe MS (10 patients, 9.2 mg/dL). In contrast, urinary uric acid to creatinine ratio was 0.42 mg/mg in patients with gout and mild MS and 0.33 mg/mg in gout patients with severe MS. Uric acid underexcretion appears to be more severe in gout patients with the MS. This disturbance appears to be related to the severity of the MS.
Databáze:	OpenAIRE
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