One-Step Protein-Polymer Conjugates from Boronic-Acid-Functionalized Polymers
| Autor: | Michael J. Swierczynski, Zachary T. Ball |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Polymers
Biomedical Engineering Pharmaceutical Science Bioengineering One-Step 02 engineering and technology 01 natural sciences Catalysis chemistry.chemical_compound Pharmacology chemistry.chemical_classification Bioconjugation 010405 organic chemistry Organic Chemistry Proteins Polymer 021001 nanoscience & nanotechnology Combinatorial chemistry Boronic Acids 0104 chemical sciences chemistry Reagent 0210 nano-technology Hybrid material Dimerization Boronic acid Biotechnology Conjugate Cysteine |
| Zdroj: | Bioconjugate chemistry. 31(11) |
| ISSN: | 1520-4812 |
| Popis: | Polymer-protein conjugates are hybrid materials with interesting and useful properties. Methods to prepare diverse diblock materials of this sort often struggle to deal with the complexity and size of reagents, and so polymer-protein conjugation represents a stringent testing ground for nontraditional bioconjugation methods, such as metal-catalyzed arylation. This work demonstrates a simple Ni2+-promoted arylation of cysteine residues with end-functionalized polymer-boronic acid reagents, and explores some molecular and physical properties possible in these hybrid structures. |
| Databáze: | OpenAIRE |
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