Biomaterial-engineering and neurobiological approaches for regenerating the injured cerebral cortex
| Autor: | Itsuki Ajioka |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Central nervous system Biomedical Engineering MSC mesenchymal stem cell V–SVZ ventricular–subventricular zone Review Article Cell cycle CNS central nervous system VZ ventricular zone Biomaterials 03 medical and health sciences 0302 clinical medicine Cortex (anatomy) medicine Regeneration lcsh:QH573-671 lcsh:R5-920 lcsh:Cytology OB olfactory bulb Regeneration (biology) ES embryonic stem Biomaterial Cerebral cortex Functional recovery 030104 developmental biology medicine.anatomical_structure MZ marginal zone NSC neural stem cell lcsh:Medicine (General) Psychology Neuroscience 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Regenerative Therapy Regenerative Therapy, Vol 3, Iss C, Pp 63-67 (2016) |
| ISSN: | 2352-3204 |
| DOI: | 10.1016/j.reth.2016.02.002 |
| Popis: | The cerebral cortex is responsible for higher functions of the central nervous system (CNS), such as movement, sensation, and cognition. When the cerebral cortex is severely injured, these functions are irreversibly impaired. Although recent neurobiological studies reveal that the cortex has the potential for regeneration, therapies for functional recovery face some technological obstacles. Biomaterials have been used to evoke regenerative potential and promote regeneration in several tissues, including the CNS. This review presents a brief overview of new therapeutic strategies for cortical regeneration from the perspectives of neurobiology and biomaterial engineering, and discusses a promising technology for evoking the regenerative potential of the cerebral cortex. Highlights • Transplanted neural or endogenous neural stem cells can promote cortical regeneration. • Strategies for cortical regeneration must address specific technical issues. • Regenerative strategies include cell-cycle manipulation and engineered biomaterials. |
| Databáze: | OpenAIRE |
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