Papillary carcinomas of the thyroid have pore-deficient nuclei
| Autor: | Manuel Sobrinho-Simões, Inga Finseth, Lars Pilström, Jan Vincents Johannessen |
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| Rok vydání: | 1982 |
| Předmět: |
Adenoma
Cancer Research Pathology medicine.medical_specialty Staining and Labeling Chemistry Nuclear Envelope Thyroid Normal thyroid Adenocarcinoma Slow growth Carcinoma Papillary Microscopy Electron medicine.anatomical_structure Oncology Follicular phase medicine Humans Papillary carcinoma Thyroid Neoplasms Nuclear pore Nuclear membrane Neoplasm Metastasis Lymph node |
| Zdroj: | International journal of cancer. 30(4) |
| ISSN: | 0020-7136 |
| Popis: | A significant reduction in nuclear pore density observed in papillary carcinomas compared to normal thyroid, adenomas and follicular carcinomas probably disturbs the nucleo-cytoplasmic transfer of ribonucleoproteins. This may contribute to the slow growth and indolent biological behavior of these tumors where even the presence of regional lymph node metastases does not worsen the prognosis. The signs of nuclear hyperactivity may result from an attempt to compensate for the nuclear membrane defect. |
| Databáze: | OpenAIRE |
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