Neutralizing Antibody Response and Antibody-Dependent Cellular Cytotoxicity in HIV-1–Infected Individuals from Guinea-Bissau and Denmark

Autor: Jan Gerstoft, Zacarias da Silva, Leo Heyndrickx, Anders Fomsgaard, Bo Langhoff Hønge, Sanne Jespersen, Gitte Kronborg, Ingrid Karlsson, Sanne Skov Jensen, Angelica A. Palm, Marie Borggren
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
HIV Antigens
Denmark
Immunology
Human immunodeficiency virus (HIV)
HIV Infections
Antibody-Dependent Cell Cytotoxicity/immunology
HIV Antibodies
HIV Envelope Protein gp120
medicine.disease_cause
HIV Antigens/immunology
Virus
HIV Infections/immunology
03 medical and health sciences
HIV Envelope Protein gp120/genetics
Acquired immunodeficiency syndrome (AIDS)
HIV-1/immunology
Virology
medicine
Humans
Guinea-Bissau
Antibodies
Neutralizing/blood
Neutralizing antibody
Cytotoxicity
env Gene Products
Human Immunodeficiency Virus/genetics
AIDS Vaccines
Antibody-dependent cell-mediated cytotoxicity
Base Sequence
biology
Antibody-Dependent Cell Cytotoxicity
env Gene Products
Human Immunodeficiency Virus
virus diseases
Base Sequence/genetics
medicine.disease
Antibodies
Neutralizing
030104 developmental biology
Infectious Diseases
Guinea bissau
HIV-1
biology.protein
AIDS Vaccines/immunology
Female
Antibody
HIV Antibodies/blood
Zdroj: Borggren, M, Jensen, S S, Heyndrickx, L, Palm, A A, Gerstoft, J, Kronborg, G, Hønge, B L, Jespersen, S, da Silva, Z J, Karlsson, I & Fomsgaard, A 2016, ' Neutralizing Antibody Response and Antibody-Dependent Cellular Cytotoxicity in HIV-1-Infected Individuals from Guinea-Bissau and Denmark ', AIDS Research and Human Retroviruses . https://doi.org/10.1089/AID.2015.0118
Borgren, M, Jensen, S S, Heyndrickx, L, Palm, A, Gerstoft, J, Kronborg, G, Hønge, B L, Jespersen, S, da Silva, Z J, Karlsson, I & Fomsgaard, A 2016, ' Neutralizing antibody response and antibody-dependent cellular cytotoxicity in HIV-1 infected individuals from Guinea-Bissau and Denmark ', AIDS Research and Human Retroviruses, vol. 32, no. 5, pp. 434-442 . https://doi.org/10.1089/AID.2015.0118
ISSN: 1931-8405
0889-2229
DOI: 10.1089/aid.2015.0118
Popis: The development of therapeutic and prophylactic HIV vaccines for African countries is urgently needed, but the question of what immunogens to use needs to be answered. One approach is to include HIV envelope immunogens derived from HIV-positive individuals from a geographically concentrated epidemic with more limited viral genetic diversity for a region-based vaccine. To address if there is a basis for a regional selected antibody vaccine, we have screened two regionally separate cohorts from Guinea-Bissau and Denmark for neutralizing antibody activity and antibody-dependent cellular cytotoxicity (ADCC) against local and nonlocal circulating HIV-1 strains. The neutralizing activity did not demonstrate higher potential against local circulating strains according to geography and subtype determination, but the plasma from Danish individuals demonstrated significantly higher inhibitory activity than that from Guinea-Bissau individuals against both local and nonlocal virus strains. Interestingly, an opposite pattern was observed with ADCC activity, where Guinea-Bissau individual plasma demonstrated higher activity than Danish plasma and was specifically against the local circulating subtype. Thus, on basis of samples from these two cohorts, no local-specific neutralizing activity was detected, but a local ADCC response was identified in the Guinea-Bissau samples, suggesting potential use of regional immunogens for an ADCC-inducing vaccine.
Databáze: OpenAIRE
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