Population-based Prospective Study of the Combined Influence of Cigarette Smoking and Helicobacter pylori Infection on Gastric Cancer Incidence: The Hisayama Study
| Autor: | Kentaro Shikata, Toshiharu Ninomiya, Yumihiro Tanizaki, Takayuki Matsumoto, Yasufumi Doi, Mitsuo Iida, Michiaki Kubo, Yutaka Kiyohara, Hisatomi Arima, Koji Yonemoto |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Rural Population medicine.medical_specialty Epidemiology Population Gastroenterology Helicobacter Infections Japan Risk Factors Stomach Neoplasms Internal medicine Humans Medicine Prospective Studies education Prospective cohort study Stomach cancer education.field_of_study biology business.industry Incidence Incidence (epidemiology) Smoking Hazard ratio Cancer Middle Aged Helicobacter pylori medicine.disease biology.organism_classification Surgery Population Surveillance Attributable risk Female business Follow-Up Studies |
| Zdroj: | American Journal of Epidemiology. 168:1409-1415 |
| ISSN: | 1476-6256 0002-9262 |
| DOI: | 10.1093/aje/kwn276 |
| Popis: | The authors assessed the separate and joint influences of cigarette smoking and Helicobacter pylori infection on the development of gastric cancer in a population-based prospective study. A total of 1,071 Japanese men aged > or =40 years were followed up prospectively for 14 years (1998-2002). Compared with that for current nonsmokers, the multivariate-adjusted hazard ratios of gastric cancer for smokers of 1-9, 10-19, and > or =20 cigarettes per day were 1.36 (95% confidence interval (CI): 0.50, 3.71), 1.93 (95% CI: 1.01, 3.67), and 1.88 (95% CI: 1.02, 3.43), respectively. The risk of gastric cancer increased steeply for subjects who had both a smoking habit and H. pylori infection compared with those who did not have both risk factors (hazard ratio = 11.41, 95% CI: 1.54, 84.67). If causal, the estimated population attributable fraction of gastric cancer for cigarette smoking was approximately half that for H. pylori infection (28.4% vs. 56.2%). The overlap of the population attributable fractions for the 2 factors was 49.6%. Findings suggest that cigarette smoking and H. pylori infection are significant risk factors for gastric cancer in Japanese men, and the magnitude of their combined influence is considerable. |
| Databáze: | OpenAIRE |
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