The long-term outcome of childhood nephrotic syndrome in Germany: a cross-sectional study
| Autor: | Lisa Kurylowicz, Michael J. Lentze, Rebekka Hagemann, Mark Born, Ingo Franke, Rainer Ganschow, Malik Aydin |
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| Rok vydání: | 2018 |
| Předmět: |
Nephrology
Adult Male medicine.medical_specialty Nephrotic Syndrome Adolescent Physiology Cross-sectional study Comorbidity Bone and Bones Young Adult Cataracts Pregnancy Recurrence Physiology (medical) Internal medicine Germany medicine Humans Risk factor Child Retrospective Studies business.industry Infant Middle Aged medicine.disease Steroid-resistant nephrotic syndrome Low birth weight Cross-Sectional Studies Fertility Child Preschool Female medicine.symptom Complication business Nephrotic syndrome |
| Zdroj: | Clinical and experimental nephrology. 23(5) |
| ISSN: | 1437-7799 |
| Popis: | Long-term outcomes of children with nephrotic syndrome have not been well described in the literature. Cross-sectional study data analysis of n = 43 patients with steroid-sensitive (SSNS) and n = 7 patients with steroid-resistant (SRNS) nephrotic syndrome were retrospectively collected; patients were clinically examined at a follow-up visit (FUV), on average 30 years after onset, there was the longest follow-up period to date. The mean age at FUV was 33.6 years (14.4–50.8 years, n = 41). The mean age of patients with SSNS at onset was 4.7 years (median 3.8 years (1.2–14.5 years), the mean number of relapses was 5.8 (0 to 29 relapses). Seven patients (16.3%) had no relapses. Eleven patients were “frequent relapsers” (25.6%) and four patients still had relapses beyond the age of 18 years. Except of cataracts and arterial hypertension, there were no negative long-term outcomes and only one patient was using immunosuppressant therapy at FUV. 55% of patients suffered from allergies and 47.5% had hypercholesterolemia. Two patients suffered a heart attack in adulthood. A younger age at onset ( |
| Databáze: | OpenAIRE |
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