Immunophenotypical alterations with impact on the epithelial–mesenchymal transition (EMT) process in salivary gland adenoid cystic carcinomas
| Autor: | Otilia Mărgăritescu, Claudiu Mărgăritescu, Maria Cristina Munteanu, Cristiana Iulia Dumitrescu, Iulia Cristiana Belulescu |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Embryology Pathology medicine.medical_specialty Epithelial-Mesenchymal Transition Adenoid cystic carcinoma invasiveness salivary gland Vimentin epithelial–mesenchymal transition Adenoid Immunophenotyping Pathology and Forensic Medicine medicine Animals Humans adenoid cystic carcinoma Epithelial–mesenchymal transition Original Paper biology Salivary gland business.industry Cell Biology General Medicine Middle Aged Salivary Gland Neoplasms medicine.disease Carcinoma Adenoid Cystic Phenotype Fibronectin stomatognathic diseases medicine.anatomical_structure immunohistochemistry biology.protein Immunohistochemistry Female business Developmental Biology |
| Zdroj: | Romanian Journal of Morphology and Embryology |
| ISSN: | 2066-8279 1220-0522 |
| DOI: | 10.47162/rjme.61.1.20 |
| Popis: | Adenoid cystic carcinoma (ACC) is one of the most common malignant salivary glands neoplasms with an indolent clinical course, slow-growing but locally aggressive and quite often with delayed recurrence and distant metastasis. In order to elucidate this tumoral behavior, we conducted an immunohistochemical study investigating the alterations of epithelial phenotype with anti-cytokeratin (CK) AE1∕AE3 and anti-E-cadherin antibodies, and the acquisition of mesenchymal phenotype with vimentin, fibronectin, N-cadherin and P-cadherin in salivary ACCs. Thus, we recorded a reduction of CK AE1∕AE3, E-cadherin, P-cadherin and fibronectin reactivity in the solid variant and especially in the cells from the periphery of invasive neoplastic proliferations, regardless histological type. These phenotypical alterations suggest the involvement of the epithelial-mesenchymal transition (EMT) process in the progression of salivary ACCs. |
| Databáze: | OpenAIRE |
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