Amyloid localized to tenosynovium at carpal tunnel release. Natural history of 124 cases
| Autor: | Ronald L. Linscheid, Robert A. Kyle, Stanley G. Eilers, Thomas A. Gaffey |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
musculoskeletal diseases
Male medicine.medical_specialty Pathology Amyloid medicine Humans Carpal tunnel Carpal tunnel syndrome Aged Aged 80 and over Ligaments business.industry Amyloidosis Synovial Membrane General Medicine Middle Aged musculoskeletal system medicine.disease Carpal Tunnel Syndrome Median nerve nervous system diseases Surgery body regions Carpal bones medicine.anatomical_structure Immunoglobulin M Rheumatoid arthritis Female Myxedema business Primary systemic amyloidosis Follow-Up Studies |
| Zdroj: | American journal of clinical pathology. 91(4) |
| ISSN: | 0002-9173 |
| Popis: | One hundred fifty-two patients with amyloid in the tenosynovium who had carpal tunnel release were identified. Twenty-eight patients were excluded because of systemic amyloidosis: primary systemic amyloidosis (AL) in 24, secondary amyloidosis (AA) in 3, and familial amyloidosis (AF) in 1. The remaining 124 patients (82%) had carpal tunnel syndrome with local deposition of amyloid and no evidence of systemic amyloidosis. Median survival of the 124 patients from diagnosis of amyloidosis was 12 years. Only two patients had systemic amyloidosis develop--9 and 10 years after recognition of tenosynovial amyloid. Of particular interest were 12 patients who had an M-protein in the serum or urine. None of the 12 patients have had evidence of systemic amyloidosis or multiple myeloma during the median follow-up of 14 years. The authors conclude that amyloid may be localized to the tenosynovium and that systemic amyloidosis rarely develops during long-term follow-up. |
| Databáze: | OpenAIRE |
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