Soluble intercellular adhesion molecule-1 is related to endothelial vasodilatory function in healthy individuals
| Autor: | Lars Lind, Johannes Hulthe, Thomas Kahan, Mahziar Sarabi, Anders Holmlund, Jonas Millgård |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Endothelium Carotid Artery Common Intercellular Adhesion Molecule-1 Vascular Cell Adhesion Molecule-1 Hemodynamics medicine.artery Internal medicine E-selectin medicine Humans cardiovascular diseases Common carotid artery Aged biology Cell adhesion molecule business.industry C-reactive protein Middle Aged Tunica intima Vasodilation C-Reactive Protein medicine.anatomical_structure Endocrinology Immunology cardiovascular system biology.protein Female Endothelium Vascular E-Selectin Tunica Intima Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Karolinska Institutet |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/s0021-9150(02)00234-4 |
| Popis: | OBJECTIVE: To investigate the associations between markers of systemic and vascular inflammation, and indicators of vascular morphology and function. METHODS: In 59 apparently healthy individuals, we measured serum levels of highly sensitive C-reactive protein (hsCRP), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin. Endothelium-dependent (EDV) and -independent (EIDV) vasodilatation was evaluated in the forearm by venous occlusion plethysmography and local infusions of methacholine and sodium nitroprussid. Endothelial function index (EFI) was expressed as the EDV/EIDV ratio. The intima-media thickness (IMT) of the common carotid artery was investigated with ultrasound (far wall). RESULTS: EFI was inversely related only to ICAM-1 (r=-0.31, P |
| Databáze: | OpenAIRE |
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