Short strides to important findings: A short interval longitudinal study of sleep quality, psychological distress and microstructure changes to the uncinate fasciculus in early adolescents
| Autor: | Daniel F. Hermens, Denise Beaudequin, Larisa T. McLoughlin, Zack Shan, Paul E. Schwenn, Jim Lagopoulos, Daniel Jamieson |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Aging Longitudinal study Uncinate Fasciculus Adolescent Uncinate fasciculus Psychological Distress White matter 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience Fractional anisotropy Humans Medicine Longitudinal Studies Child Myelin Sheath 030304 developmental biology 0303 health sciences Sleep quality business.industry White Matter Sleep in non-human animals Diffusion Tensor Imaging medicine.anatomical_structure Anisotropy Early adolescents Female Self Report Sleep business 030217 neurology & neurosurgery Developmental Biology Clinical psychology Diffusion MRI |
| Zdroj: | International Journal of Developmental Neuroscience. 81:82-90 |
| ISSN: | 1873-474X 0736-5748 |
| Popis: | BACKGROUND Developmental studies have shown adolescence is a period of ongoing white matter (WM) development, reduced sleep quality and the onset of many mental disorders. Findings indicate the WM development of the uncinate fasciculus (UF), a WM tract suggested to play a key role in mental disorders, continues throughout adolescence. While these studies provide valuable information, they are limited by long intervals between scans (1 to 4 years) leaving researchers and clinicians to infer what may be occurring between time-points. To allow inferences to be made regarding the impact that sleep quality may be having on WM development, longitudinal studies with much shorter between-scan intervals are required. METHODS The current study reports longitudinal data of self-reported sleep quality (PSQI), diffusion tensor imaging (DTI) measures of WM development and psychological distress (K10) for n = 64 early adolescents spanning the first twelve months (four time-points; Baseline, 4, 8, & 12 months) of the Longitudinal Adolescent Brain Study (LABS) study currently underway at the Thompson Institute. RESULTS Generalised Estimating Equation analysis showed a significant relationship between sleep quality and psychological distress over the four time-points. Reduced radial diffusivity and increased fractional anisotropy of the UF is also reported with increasing age suggesting that ongoing myelination is occurring. Adding sleep quality to the model, however, negatively impacted this myelination process. CONCLUSION These findings represent an important step towards elucidating how sleep, psychological distress and maturation of the UF may co-develop during early adolescence. |
| Databáze: | OpenAIRE |
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