Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (Cinnamosma sp.) Extracts and Drimane-Type Sesquiterpenes against Aedes aegypti Mosquitoes
| Autor: | Preston K. Manwill, Xiaolin Cheng, Annecie Benatrehina, L. Harinantenaina Rakotondraibe, Bao Nguyen, Sijin Wu, Edna Alfaro Inocente, Eliningaya J. Kweka, Peter M. Piermarini |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
food.ingredient
Warburgia ugandensis 030231 tropical medicine Polygodial Aedes aegypti Warburgia 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine food lcsh:Science warburgia 030304 developmental biology 0303 health sciences Canellaceae biology Traditional medicine antifeedant aedes aegypti fungi insecticide biology.organism_classification 3. Good health Mosquito control chemistry Insect Science visual_art cinnamosma visual_art.visual_art_medium Cinnamosma Bark lcsh:Q |
| Zdroj: | Insects, Vol 10, Iss 11, p 373 (2019) Insects Volume 10 Issue 11 |
| ISSN: | 2075-4450 |
| Popis: | The overuse of insecticides with limited modes of action has led to resistance in mosquito vectors. Thus, insecticides with novel modes of action are needed. Secondary metabolites in Madagascan plants of the genus Cinnamosma (Canellaceae) are commonly used in traditional remedies and known to elicit antifeedant and toxic effects in insect pests. Here we test the hypothesis that extracts of Cinnamosma sp. enriched in drimane sesquiterpenes are toxic and/or antifeedant to the yellow fever mosquito Aedes aegypti. We show that the bark and root extracts, which contain a higher abundance of drimane sesquiterpenes compared to leaves, were the most efficacious. Screening isolated compounds revealed cinnamodial to be the primary driver of adulticidal activity, whereas cinnamodial, polygodial, cinnafragrin A, and capsicodendrin contributed to the larvicidal activity. Moreover, an abundant lactone (cinnamosmolide) in the root extract synergized the larvicidal effects of cinnamodial. The antifeedant activity of the extracts was primarily contributed to cinnamodial, polygodial, and cinnamolide. Parallel experiments with warburganal isolated from Warburgia ugandensis (Canellaceae) revealed that aldehydes are critical for&mdash and a hydroxyl modulates&mdash insecticidal activity. Our results indicate that plant drimane sesquiterpenes provide valuable chemical platforms for developing insecticides and repellents to control mosquito vectors. |
| Databáze: | OpenAIRE |
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