Basement membrane components are key players in specialized extracellular matrices
| Autor: | Nicolai Miosge, Jenny Kruegel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Collagen Type IV
Basement membrane Cell Culture Techniques Review Extracellular matrix 03 medical and health sciences Cellular and Molecular Neuroscience Mice 0302 clinical medicine Laminin Extracellular medicine Animals Humans Molecular Biology 030304 developmental biology Cancer Pharmacology 0303 health sciences Membrane Glycoproteins biology Tissue Engineering Stem Cells Chemotaxis Cell Biology Stem cell niche Embryonic stem cell Cell biology Extracellular Matrix medicine.anatomical_structure 030220 oncology & carcinogenesis Epithelial mesenchymal transition biology.protein Life Sciences Biochemistry general Life Sciences general Biomedicine general Molecular Medicine Stem cell Heparan Sulfate Proteoglycans Adult stem cell |
| Zdroj: | Cellular and Molecular Life Sciences |
| ISSN: | 1420-9071 1420-682X |
| Popis: | More than three decades ago, basement membranes (BMs) were described as membrane-like structures capable of isolating a cell from and connecting a cell to its environment. Since this time, it has been revealed that BMs are specialized extracellular matrices (sECMs) with unique components that support important functions including differentiation, proliferation, migration, and chemotaxis of cells during development. The composition of these sECM is as unique as the tissues to which they are localized, opening the possibility that such matrices can fulfill distinct functions. Changes in BM composition play significant roles in facilitating the development of various diseases. Furthermore, tissues have to provide sECM for their stem cells during development and for their adult life. Here, we briefly review the latest research on these unique sECM and their components with a special emphasis on embryonic and adult stem cells and their niches. peerReviewed |
| Databáze: | OpenAIRE |
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