Statins and the risk of polyneuropathy: A systematic review and two meta-analyses
| Autor: | Thapat Wannarong, Patompong Ungprasert, Thanat Chaikijurajai, Persen Sukpornchairak, Weerakit Naweera, David C. Preston |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Variance method
medicine.medical_specialty Physiology business.industry MEDLINE Odds ratio medicine.disease Confidence interval Cellular and Molecular Neuroscience Polyneuropathies Standard error Physiology (medical) Internal medicine Meta-analysis Case-Control Studies Cohort medicine Diabetes Mellitus Odds Ratio Humans Neurology (clinical) Hydroxymethylglutaryl-CoA Reductase Inhibitors business Polyneuropathy |
| Zdroj: | MusclenerveREFERENCES. 65(1) |
| ISSN: | 1097-4598 |
| Popis: | INTRODUCTION/AIMS Previous studies have shown inconsistent data on the relationship between statin use and polyneuropathy (PN). The current systematic review and meta-analyses were conducted to comprehensively investigate the risk of incident PN among statin-users compared with non-users by identifying all available studies and summarizing their results. METHODS A systematic review was conducted from MEDLINE and EMBASE databases from inception to October 31, 2020. We included cohort and case-control studies that compared the risk of incident PN between statin-users and non-users. Point estimates and standard errors from eligible studies were pooled together using the generic inverse variance method. RESULTS Of 4968 retrieved articles, 6 studies in non-diabetic populations and 2 studies in diabetic populations fulfilled the inclusion criteria. Two meta-analyses were performed. The pooled analyses did not find a statistically significant association between the use of statins and risk of incident PN with the pooled odds ratio of 1.24 (95% confidence interval [CI], 0.88-1.76; I2 74%) and 0.82 (95% CI, 0.56-1.21; I2 80%) in non-diabetic and diabetic groups respectively. DISCUSSION No significant association between the use of statins and the risk of PN was observed in this systematic review and these two meta-analyses. However, there was a high degree of heterogeneity of the meta-analyses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text