Self-Assembly of Bile Acid–PEG Conjugates in Aqueous Solutions

Autor:	Frantz Le Dévédec, X. X. Zhu, Satu Strandman
Rok vydání:	2012
Předmět:	Thixotropy Lithocholic acid Aqueous solution Bile acid medicine.drug_class Surfaces Coatings and Films Dilution chemistry.chemical_compound chemistry Chemical engineering PEG ratio Materials Chemistry medicine Organic chemistry Self-assembly Physical and Theoretical Chemistry Ethylene glycol
Zdroj:	The Journal of Physical Chemistry B. 117:252-258
ISSN:	1520-5207 1520-6106
Popis:	Thermoresponsive characteristics of oligo(ethylene glycol) derivatives of lithocholic acid (LCA) depend on the hydrophilic/hydrophobic balance of the compounds. Below a threshold temperature (∼30 °C), one of the derivatives, LCA(EG(4))(2), self-assembles in water into hollow nanotubes that form thixotropic gels at high concentrations. Two concentration regimes were observed in the plateau moduli (G(0) ∼ G'). At high concentrations, the mobility of the nanotubes is restricted at the ordered microdomains acting as cross-links. In semidilute aqueous solutions, the linkers between the aggregated domains in the fragile gel rupture easily, and this effect depends strongly on dilution. Organic hydrophobic additives perturb the self-assembling process, leading to changes in the two transition temperatures and poorer mechanical properties of the gel.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3928a89e9716bbe8f8ebd2663baedeef https://doi.org/10.1021/jp307989a Zobrazit plný text záznamu