Enkephalin release from VIP interneurons in the hippocampal CA2/3a region mediates heterosynaptic plasticity and social memory
| Autor: | Eric R. Kandel, Felix Leroy, Steven A. Siegelbaum, Olivia M Lofaro, Christopher A. de Solis, Lara M. Boyle, Eric W. Buss, Arun Asok, Tobias Bock |
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| Přispěvatelé: | Brain and Behavior Research Foundation, Howard Hughes Medical Institute |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Chemistry Vasoactive intestinal peptide Heterosynaptic plasticity Neuropeptide Hippocampus Inhibitory postsynaptic potential 03 medical and health sciences Cellular and Molecular Neuroscience Psychiatry and Mental health 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure nervous system Synaptic plasticity medicine GABAergic Neuron Molecular Biology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | The hippocampus contains a diverse array of inhibitory interneurons that gate information flow through local cortico-hippocampal circuits to regulate memory storage. Although most studies of interneurons have focused on their role in fast synaptic inhibition mediated by GABA release, different classes of interneurons express unique sets of neuropeptides, many of which have been shown to exert powerful effects on neuronal function and memory when applied pharmacologically. However, relatively little is known about whether and how release of endogenous neuropeptides from inhibitory cells contributes to their behavioral role in regulating memory formation. Here we report that vasoactive intestinal peptide (VIP)-expressing interneurons participate in social memory storage by enhancing information transfer from hippocampal CA3 pyramidal neurons to CA2 pyramidal neurons. Notably, this action depends on release of the neuropeptide enkephalin from VIP neurons, causing long-term depression of feedforward inhibition onto CA2 pyramidal cells. Moreover, VIP neuron activity in the CA2 region is increased selectively during exploration of a novel conspecific. Our findings, thus, enhance our appreciation of how GABAergic neurons can regulate synaptic plasticity and mnemonic behavior by demonstrating that such actions can be mediated by release of a specific neuropeptide, rather than through classic fast inhibitory transmission. This work was supported by: a 2019 NARSAD young investigator grant to FL from the Brain and Behavior research foundation, funded by the Osterhaus Family; a F32 MH122147-01A1 to CdS; Howard Hughes Medical Institute support to ERK and R01-MH104602 and R01-MH106629 to SAS. |
| Databáze: | OpenAIRE |
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