Bone-brain crosstalk and potential associated diseases
| Autor: | Mariana Ramos-Brossier, Audrey Rousseaud, Franck Oury, Stéphanie Moriceau |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cell signaling Brain development Endocrinology Diabetes and Metabolism Osteoporosis Central nervous system Regulator Cell Communication Bone and Bones 03 medical and health sciences Endocrinology medicine Animals Humans Molecular Biology biology Brain Diseases Metabolic Brain General Medicine medicine.disease Bone Diseases Metabolic Crosstalk (biology) 030104 developmental biology medicine.anatomical_structure Osteocalcin biology.protein Neuroscience Homeostasis |
| Zdroj: | Hormone Molecular Biology and Clinical Investigation. 28:69-83 |
| ISSN: | 1868-1891 1868-1883 |
| DOI: | 10.1515/hmbci-2016-0030 |
| Popis: | Reciprocal relationships between organs are essential to maintain whole body homeostasis. An exciting interplay between two apparently unrelated organs, the bone and the brain, has emerged recently. Indeed, it is now well established that the brain is a powerful regulator of skeletal homeostasis via a complex network of numerous players and pathways. In turn, bone via a bone-derived molecule, osteocalcin, appears as an important factor influencing the central nervous system by regulating brain development and several cognitive functions. In this paper we will discuss this complex and intimate relationship, as well as several pathologic conditions that may reinforce their potential interdependence. |
| Databáze: | OpenAIRE |
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