Echocardiographic evaluation of cardiac structure and function in elderly subjects with isolated systolic hypertension
| Autor: | Jerome D. Cohen, David A. Nagelhout, Arthur J. Labovitz, James Sear, Chalapathirao Gudipati, Anthony C. Pearson |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Systolic hypertension Systole Diastole Blood Pressure Cardiomegaly Doppler echocardiography Left ventricular hypertrophy Ventricular Function Left Internal medicine Medicine Humans Cardiac structure Aged medicine.diagnostic_test business.industry medicine.disease Control subjects Echocardiography Doppler Blood pressure Isolated systolic hypertension Hypertension Cardiology Female business Cardiology and Cardiovascular Medicine |
| Zdroj: | Journal of the American College of Cardiology. 17(2) |
| ISSN: | 0735-1097 |
| Popis: | One hundred four participants in the Systolic Hypertension in the Elderly Program (SHEP) trial (mean age 71 +/- 6 years) were examined by Doppler echocardiography to gain information on the cardiac structural and functional alterations in isolated systolic hypertension. Participants had a systolic blood pressure greater than 160 mm Hg with diastolic blood pressure less than 90 mm Hg and were compared with 55 age-matched normotensive control subjects. Left ventricular mass index was significantly higher in the participants than in the normotensive subjects (103 +/- 28 versus 87 +/- 23 g/m2, p = 0.0014) and 26% of the participants met echocardiographic criteria for left ventricular hypertrophy compared with 10% of normotensive subjects. Left atrial index was also greater in participants than in normotensive subjects (2.26 +/- 0.32 versus 2.11 +/- 0.24 cm/m2, p = 0.005) and 51% of participants had left atrial enlargement. Doppler measures of diastolic filling were significantly different between the two groups, with peak atrial velocity higher (76 +/- 17 versus 69 +/- 17 cm/s, p = 0.02) and ratio of peak early to atrial velocity lower (0.76 +/- 0.23 versus 0.86 +/- 0.22, p = 0.0124) in participants. There was no correlation between left ventricular mass index and Doppler measures of diastolic function, but relative wall thickness correlated significantly with peak atrial velocity (r = 0.22, p = 0.016) and peak early to peak atrial velocity ratio (r = 0.24, p = 0.007). There was no difference in M-mode ejection phase indexes of systolic performance (shortening fraction and peak velocity of circumferential fiber shortening) between the two groups.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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