Plasma Cell Myeloma: Biology and Treatment
| Autor: | Daniel E. Bergsagel |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Chromosome Aberrations
Chemotherapy Cell growth business.industry medicine.medical_treatment Chromosome Disorders General Medicine medicine.disease General Biochemistry Genetics and Molecular Biology Malignant transformation Blood cell Cell Transformation Neoplastic medicine.anatomical_structure Maintenance therapy Precursor cell Immunology Plasma Cell Myeloma Cancer research Humans Medicine Multiple Myeloma business Multiple myeloma |
| Zdroj: | Annual Review of Medicine. 42:167-178 |
| ISSN: | 1545-326X 0066-4219 |
| DOI: | 10.1146/annurev.me.42.020191.001123 |
| Popis: | Plasma cell myeloma results from malignant transformation in an early hemopoietic precursor cell. The disease progresses from an asymptomatic stable phase through a symptomatic phase to a terminal acute phase marked by aggressive cell growth and marrow failure. The activation of a series of oncogenes may govern the initiation and stepwise progression of these neoplasms. Chemotherapy causes the tumor to regress in about 50% of patients and improves survival, but it does not alter the course of the disease. Interferon maintenance therapy prolongs remission durations and appears to alter the course of the disease. |
| Databáze: | OpenAIRE |
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