ESCRT-dependent cargo sorting at multivesicular endosomes
| Autor: | Anjon Audhya, E. B. Frankel |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
ESCRT Machinery biology Endosomal Sorting Complexes Required for Transport Endosome Vesicle Sorting Multivesicular Bodies Endosome lumen Biological Transport Cell Biology Limiting macromolecular substances Endosomes ESCRT Article Cell biology 03 medical and health sciences 030104 developmental biology Ubiquitin biology.protein Animals Humans Developmental Biology |
| Zdroj: | Seminars in celldevelopmental biology. 74 |
| ISSN: | 1096-3634 |
| Popis: | The endosomal sorting complex required for transport (ESCRT) machinery is composed of five multi-subunit protein complexes, which act cooperatively at specialized endosomes to facilitate the movement of specific cargoes from the limiting membrane into vesicles that bud into the endosome lumen. Over the past decade, numerous proteins, lipids, and RNAs have been shown to be incorporated into intralumenal vesicles (ILVs), but the mechanisms by which these unique cargoes are captured are only now becoming better understood. Here, we discuss the potential roles that the ESCRT machinery plays during cargo sorting at multivesicular endosomes (MVEs). |
| Databáze: | OpenAIRE |
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