Dual-Modal Imaging and Synergistic Spinal Tumor Therapy Enabled by Hierarchical-Structured Nanofibers with Cascade Release and Postoperative Anti-adhesion
| Autor: | Jiaqi Qian, Lichao Su, Jingjing He, Renjie Ruan, Jun Wang, Ziyi Wang, Peijie Xiao, Changhua Liu, Yang Cao, Weidong Li, Jin Zhang, Jibin Song, Huanghao Yang |
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| Rok vydání: | 2022 |
| Předmět: |
Spinal Neoplasms
Nanofibers General Engineering General Physics and Astronomy Serum Albumin Bovine Oxides Tissue Adhesions Hydrogen Peroxide Glutathione Manganese Compounds Doxorubicin Delayed-Action Preparations Neoplasms Cell Line Tumor Tumor Microenvironment Humans Nanoparticles General Materials Science |
| Zdroj: | ACS Nano. 16:16880-16897 |
| ISSN: | 1936-086X 1936-0851 |
| DOI: | 10.1021/acsnano.2c06848 |
| Popis: | Most treatments for spinal cancer are accompanied by serious side effects including subsequent tumor recurrence, spinal cord compression, and tissue adhesion, thus a highly effective treatment is crucial for preserving spinal and neurological functionalities. Herein, trilayered electrospun doxorubicin@bovine serum albumin/poly(ε-caprolactone)/manganese dioxide (DOX@BSA/PCL/MnO |
| Databáze: | OpenAIRE |
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