Aminopyrine infusion breath test for the determination of changes in P450 metabolism in vivo
| Autor: | A. N. Kotake, M. L. Phan, T. J. Shinn, S. K. Kuwahara, B. D. Schreider |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Health
Toxicology and Mutagenesis Analgesic Pharmacology Toxicology Biochemistry Rats Sprague-Dawley chemistry.chemical_compound Cytochrome P-450 Enzyme System In vivo medicine Animals Cytochrome P-450 Enzyme Inhibitors Expiration Carbon Radioisotopes Cimetidine Aminopyrine Breath test medicine.diagnostic_test Chemistry General Medicine Metabolism Rats Breath Tests Aminophenazone Perfusion medicine.drug |
| Zdroj: | Xenobiotica; the fate of foreign compounds in biological systems. 25(9) |
| ISSN: | 0049-8254 |
| Popis: | 1. An osmotic mini-pump was used to maintain a constant infusion of radiolabelled [N-dimethyl-14C] aminopyrine into a rat. After implanting the mini-pump, 14CO2 expiration rate was constant within 12 h, and this rate was maintained for 192 h. 2. Treatment with 2-diethylaminoethyl-2,2-diphenylvalerate HCl (SKF 525-A) or cimetidine, inhibitors of P450-dependent metabolism, resulted in both dose- and time-dependent inhibition of the expiration of 14CO2. |
| Databáze: | OpenAIRE |
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