The treatment of early Parkinson's disease
| Autor: | Ad Hovestadt, Bastiaan R. Bloem, Teus van Laar, Annemarie M. M. Vlaar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Levodopa Dyskinesia Drug-Induced Parkinson's disease Combination therapy Levodopa/administration & dosage Dopamine Agents Drug Resistance Disease Central nervous system disease Degenerative disease medicine Humans Intensive care medicine Parkinson Disease/drug therapy Dyskinesia business.industry Parkinson Disease General Medicine medicine.disease Comorbidity nervous system diseases Dopamine Agents/administration & dosage Drug-Induced/epidemiology Physical therapy Drug Resistance/physiology Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Practical Neurology. 11(3):145-152 |
| ISSN: | 1474-7758 |
| Popis: | Many clinicians regard levodopa as a last resort in the symptomatic treatment of Parkinson's disease. Here we critically review the arguments that are typically used to postpone the start of levodopa for as long as possible. We will point out that most concerns are invalid. Levodopa remains the most effective and best tolerated Parkinson's drug to date, and should have an important role in all therapeutic strategies, both as monotherapy in early Parkinson's disease and as part of combination therapy in advanced disease. Regardless of disease stage, the choice of a particular drug should not be driven by fear of long term complications but by the clinical condition of the patient at the time, with an emphasis on functioning in everyday life and any comorbidity. A 'phobia' for levodopa—or, indeed, for any other antiparkinsonian medication—is unacceptable according to current evidence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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