Low frequency of plasma nerve-growth factor detection is associated with death of memory B lymphocytes in HIV-1 infection
| Autor: | Anders Sönnerborg, A. De Milito, Anna Nilsson, S. Grutzmeier, C. Mörch, Astrid Samuelsson, Kehmia Titanji, Maurizio Zazzi |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Programmed cell death Fas Ligand Protein medicine.medical_treatment Immunology HIV Infections Biology Lymphocyte Activation Statistics Nonparametric Fas ligand Internal medicine Nerve Growth Factor Clinical Studies medicine Humans Immunology and Allergy Lymphocyte Count fas Receptor Autocrine signalling Memory B cell Cells Cultured Autoantibodies B-Lymphocytes Membrane Glycoproteins Cell Death Growth factor Flow Cytometry Tumor Necrosis Factor Receptor Superfamily Member 7 Endocrinology Nerve growth factor Cytokine Apoptosis Case-Control Studies Immunologic Memory |
| Zdroj: | Clinical and Experimental Immunology. 132:297-303 |
| ISSN: | 1365-2249 0009-9104 |
| Popis: | SUMMARYNerve growth factor (NGF) regulates B cell activation and differentiation and is an autocrine survival factor for memory B lymphocytes. We have reported recently that the number of memory B cells is reduced during HIV-1 infection. In this study we evaluated whether alteration in the NGF supply was involved in memory B cell loss in HIV-1-infected subjects. High rate of cell death in vitro was observed in memory B cells from HIV-1-infected individuals compared to uninfected donors (26·2 ± 2·5%versus 7·9 ± 1·4%, P |
| Databáze: | OpenAIRE |
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