Ibuprofen penetration enhance by sucrose ester examined by ATR-FTIR in vivo
| Autor: | Piroska Szabó-Révész, Erzsébet Csányi, Szilvia Berkó, Ottó Berkesi, Eszter Csizmazia, Gábor Eros |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Sucrose Administration Topical Skin Absorption Lipid Bilayers Pharmaceutical Science Ibuprofen Excipients chemistry.chemical_compound Mice Surface-Active Agents In vivo Spectroscopy Fourier Transform Infrared medicine Stratum corneum Animals Lipid bilayer Mice Hairless Chromatography integumentary system Anti-Inflammatory Agents Non-Steroidal Hydrogels General Medicine Penetration (firestop) Hairless medicine.anatomical_structure chemistry Self-healing hydrogels Rabbits medicine.drug |
| Zdroj: | Pharmaceutical development and technology. 17(1) |
| ISSN: | 1097-9867 |
| Popis: | The aim of this work was to investigate the skin penetration enhancer effect of a sucrose ester (SE) in an Ibuprofen (IBU) containing hydrogel and to examine its influence on the special lipid bilayer of the stratum corneum (SC). ATR-FTIR spectroscopic measurements were performed combined with tape stripping method on hairless mice in vivo. A SE containing gel was compared to another gel without SE. It was found that the preparations caused only minimal modifications in the lipid and the protein structure, promoting the skin hydration and therefore also the penetration of IBU. Although the degree of moisturization and penetration were more intense in the case of the SE containing gel treatment, it did not cause greater alterations in the SC structure than the gel without SE. It has been proven that SE acts as an effective and non-irritating hydration and penetration enhancer for IBU through skin. |
| Databáze: | OpenAIRE |
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