Risk of stroke in hospitalized SARS-CoV-2 infected patients: A multinational study
| Autor: | Shailesh Male, Martin Punter, Ramin Zand, Behnam Rezai Jahromi, Oluwaseyi Olulana, Nima Ostadrahimi, Seyed Amir Ebrahimzadeh, Sotirios Tsiodras, Mohammad Ghorbani, Mahsa Mashayekhi, Christoph J. Griessenauer, Achille Cernigliaro, Stefania Mondello, Vida Abedi, Annemarei Ranta, Shima Shahjouei, Orkhan Alizada, Apoorva Dev, Ayesha Khan, Saeideh Neshin Aghayari Sheikh, Ghasem Farahmand, Arash Kia, Alia Saberi, Emmanouil Karofylakis, Ashkan Mowla, Sakineh Ranji-Burachaloo, Mahtab Ramezani, Nitin Goyal, Seyed Aidin Sajedi, Venkatesh Avula, Reza Bavarsad Shahripour, Jiang Li, Durgesh Chaudhary, Soheil Naderi, Mehmet Hanci, Paraskevi C. Fragkou, Mika Niemelä, Mirna Sabra, Nasrin Rahimian, Alaleh Vaghefi far, Faezeh Khodadadi, Askar Ghorbani, Peyman Nowrouzi-Sohrabi, Georgios Tsivgoulis |
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| Přispěvatelé: | İÜC, Cerrahpaşa Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Department of Neurosciences, HUS Neurocenter, Neurokirurgian yksikkö, Helsinki University Hospital Area |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Cerebrovascular disorders medicine.medical_treatment lcsh:Medicine Logistic regression 3124 Neurology and psychiatry Intracranial haemorrhage Tertiary Care Centers 0302 clinical medicine Risk Factors Pandemic Venous thrombosis Viral Stroke lcsh:R5-920 STATEMENT COVID-19 Neurological complications SARS-CoV-2 Adult Aged Betacoronavirus Coronavirus Infections Female Hospitalization Humans Middle Aged Pandemics Pneumonia Viral General Medicine Thrombosis 3. Good health 030220 oncology & carcinogenesis lcsh:Medicine (General) medicine.medical_specialty Subarachnoid hemorrhage Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Internal medicine medicine Mechanical ventilation business.industry lcsh:R 3112 Neurosciences Pneumonia medicine.disease 030104 developmental biology 3121 General medicine internal medicine and other clinical medicine ONSET ATRIAL-FIBRILLATION Observational study business |
| Zdroj: | EBioMedicine, Vol 59, Iss, Pp 102939-(2020) EBioMedicine |
| ISSN: | 2352-3964 |
| Popis: | Mondello, Stefania/0000-0002-8587-3614; Alizada, Orkhan/0000-0003-0942-9906; Ghorbani, Mohammad/0000-0002-7709-3095; Abedi, Vida/0000-0001-7689-933X WOS:000575454600010 PubMed ID: 32818804 Background: There is an increased attention to stroke following SARS-CoV-2. The goal of this study was to better depict the short-term risk of stroke and its associated factors among SARS-CoV-2 hospitalized patients. Methods: This multicentre, multinational observational study includes hospitalized SARS-CoV-2 patients from North and South America (United States, Canada, and Brazil), Europe (Greece, Italy, Finland, and Turkey), Asia (Lebanon, Iran, and India), and Oceania (New Zealand). The outcome was the risk of subsequent stroke. Centres were included by non-probability sampling. The counts and clinical characteristics including laboratory findings and imaging of the patients with and without a subsequent stroke were recorded according to a predefined protocol. Quality, risk of bias, and heterogeneity assessments were conducted according to ROBINS-E and Cochrane Q-test. The risk of subsequent stroke was estimated through meta-analyses with random effect models. Bivariate logistic regression was used to determine the parameters with predictive outcome value. The study was reported according to the STROBE, MOOSE, and EQUATOR guidelines. Findings: We received data from 26,175 hospitalized SARS-CoV-2 patients from 99 tertiary centres in 65 regions of 11 countries until May 1st, 2020. A total of 17,799 patients were included in meta-analyses. Among them, 156(0.9%) patients had a stroke-123(79%) ischaemic stroke, 27(17%) intracerebral/subarachnoid hemorrhage, and 6(4%) cerebral sinus thrombosis. Subsequent stroke risks calculated with meta-analyses, under low to moderate heterogeneity, were 0.5% among all centres in all countries, and 0.7% among countries with higher health expenditures. The need for mechanical ventilation (OR: 1.9, 95% CI:1.1-3.5, p = 0.03) and the presence of ischaemic heart disease (OR: 2.5, 95% CI:1.4-4.7, p = 0.006) were predictive of stroke. Interpretation: The results of this multi-national study on hospitalized patients with SARS-CoV-2 infection indicated an overall stroke risk of 0.5%(pooled risk: 0.9%). The need for mechanical ventilation and the history of ischaemic heart disease are the independent predictors of stroke among SARS-CoV-2 patients. (C) 2020 The Authors. Published by Elsevier B.V. |
| Databáze: | OpenAIRE |
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