Prevalence of Sjögren's-like syndrome in a cohort of HIV-1-positive patients: descriptive pathology and immunopathology
| Autor: | E Kavouklis, S. Paikos, H. M. Moutsopoulos, Theodore Kordossis, V Alevizou, P Kitsanta, P Kyriaki, K. Aroni, A. Dimitrakopoulos, Fotini N. Skopouli |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Systemic disease Pathology medicine.medical_specialty Sexual Behavior Population Keratoconjunctivitis Sicca Salivary Glands Minor Autoantigens Xerostomia Cohort Studies stomatognathic system Rheumatology Immunopathology Surveys and Questionnaires Biopsy HIV Seropositivity RNA Small Cytoplasmic medicine Prevalence Humans Pharmacology (medical) Prospective Studies education Prospective cohort study Substance Abuse Intravenous education.field_of_study medicine.diagnostic_test Greece Diffuse infiltrative lymphocytosis syndrome business.industry Hypergammaglobulinemia Middle Aged medicine.disease eye diseases Parotid gland stomatognathic diseases medicine.anatomical_structure Sjogren's Syndrome Ribonucleoproteins HIV-1 Female business |
| Zdroj: | British journal of rheumatology. 37(6) |
| ISSN: | 0263-7103 |
| Popis: | The aims of the study were (a) to investigate the prevalence of Sjogren's-like syndrome (SLS) in an unselected population of HIV-1-positive patients and (b) to describe the pathology and immunopathology of the labial minor salivary gland biopsy. Seventy-seven HIV-1-positive patients were asked to answer the validated questionnaire of the European preliminary criteria for the classification of Sjogren's syndrome on oral and ocular sicca symptoms. Twenty-six patients gave one positive answer to both ocular and oral symptoms, and of these 14 (hepatitis C virus negative) consented to participate in the study (patients group). Ten age- and sex-matched HIV-1-positive patients with a negative questionnaire constituted the control group. Patients and controls had: (a) Schirmer's test and slit-lamp examination after Rose Bengal staining; (b) parotid gland scanning with technetium; (c) detection of autoantibodies in sera to Ro/SSA and La/SSB; (d) labial salivary gland biopsy (patients group only). The control group gave negative parotid gland scanning and only one gave a positive Rose Bengal staining test. In the patients group, parotid gland enlargement was manifested by three patients and only one gave positive Rose Bengal staining test. Six out of the 14 patients had biopsies identical with Sjogren's syndrome and five of these gave positive parotid gland scanning. In the biopsies of four other patients, mucoid degeneration of the stroma was found. Immunopathology revealed that the predominant cells were T cells with the CD8 phenotype. None of the patient and control sera had autoantibodies to Ro/SSA and La/SSB, whereas all patients had hypergammaglobulinaemia. The overall prevalence of possible SLS in a mixed population of HIV(+) patients (88.3% men and 11.7% women) was 7.79% which is >2.5 times higher than that observed in normal Greek adult females. |
| Databáze: | OpenAIRE |
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