Retinoic acids up-regulate functional eosinophil-driving receptor CCR3
| Autor: | Yoshimi Kobayashi, Junko Nishikawa, Shigeharu Ueki, Wataru Ito, Junichi Chihara, Yasunori Konno, Yuki Moritoki, Masahide Takeda, Mami Tamaki, Yumiko Yamauchi, Masamichi Itoga |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Chemotactic Factors Eosinophil Receptors CCR3 Immunology CCR3 Tretinoin Retinoic acid receptor beta Biology Sensitivity and Specificity Dermatitis Atopic Retinoic acid-inducible orphan G protein-coupled receptor immune system diseases Internal medicine medicine Humans Immunology and Allergy Receptor Cells Cultured CCL11 Chemokine CCL24 hemic and immune systems respiratory system Eosinophil Up-Regulation Eosinophils Chemotaxis Leukocyte Retinoic acid receptor medicine.anatomical_structure Endocrinology Gene Expression Regulation Retinoic acid receptor alpha Signal Transduction |
| Zdroj: | Allergy. 68:953-956 |
| ISSN: | 0105-4538 |
| DOI: | 10.1111/all.12175 |
| Popis: | Eotaxins and their receptor CCR3 have a definitive role for tissue accumulation of eosinophils both under homeostatic and pathologic conditions. However, physiological stimuli that can up-regulate CCR3 in blood-derived human eosinophils have not been recognized. As a prior gene microarray study revealed up-regulation of CCR3 in eosinophils stimulated with retinoic acids (RAs), the expression of functional CCR3 was examined. We found that 9-cis RA and all-trans RA (ATRA) significantly induced surface CCR3 expression regardless of the presence of IL-3 or IL-5. Pharmacological manipulations with receptor-specific agonists and antagonists indicated that retinoic acid receptor-α activation is critical for CCR3 up-regulation. RA-induced CCR3 was associated with its functional capacity, in terms of the calcium mobilization and chemotactic response to eotaxin-1 (CCL11). Our study suggests an important role of vitamin A derivatives in the tissue accumulation of eosinophils. |
| Databáze: | OpenAIRE |
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