Controlled ovarian hyperstimulation for low responders in in vitro fertilization/intracytoplasmic sperm injection: a low-dose flare protocol
| Autor: | Luca Sabatini, Talha Al-Shawaf, Colin Davis, Ariel Zosmer, Adrija Kumar Datta, A. Tozer, S. Vitthala |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Pregnancy Rate medicine.medical_treatment Urology Fertilization in Vitro Controlled ovarian hyperstimulation Drug Administration Schedule Intracytoplasmic sperm injection law.invention Ovulation Induction Randomized controlled trial Pregnancy law medicine Humans Sperm Injections Intracytoplasmic Treatment Failure Birth Rate Retrospective Studies Gynecology In vitro fertilisation Dose-Response Relationship Drug integumentary system business.industry Low dose Obstetrics and Gynecology Retrospective cohort study Fertility Agents Female Low responder Reproductive Medicine Female business Live birth Infertility Female |
| Zdroj: | Fertility and Sterility. 95:1809-1812 |
| ISSN: | 0015-0282 |
| Popis: | In this retrospective study of 652 anticipated low response women, the overall clinical outcomes (live birth rate and clinical pregnancy rate [PR]) of low-dose flare (LDF) protocol appeared lower than those of conventional down-regulation (DR) (LDF: 15.1% vs. DR: 20.6% and LDF: 10.3% vs. DR: 17.4%, respectively). The findings that LDF protocol improved the clinical outcome in older women, or when LDF followed an unsuccessful IVF/intracytoplasmic sperm injection (ICSI) cycle with DR (LDF: 19.4% vs. DR: 9.76% and LDF: 13.9% vs. DR: 4.2% respectively), need further evaluation through randomized trials. |
| Databáze: | OpenAIRE |
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