A selective cyclooxygenase-2 inhibitor suppresses tumor growth in nude mouse xenografted with human head and neck squamous carcinoma cells

Autor: Hiromi Mizuno, Koji Kawakami, Goshi Nishimura, Mamoru Tsukuda, Syunsuke Yanoma
Rok vydání: 1999
Předmět:
Cytotoxicity
Immunologic
Cancer Research
medicine.medical_specialty
Telomerase
Angiogenesis
Transplantation
Heterologous
Mice
Nude
Head and neck squamous carcinoma cells
Biology
KB Cells
Article
Cell cycle arrest
Mice
Nude mouse
Internal medicine
medicine
Animals
Humans
Cyclooxygenase Inhibitors
Killer Cells
Lymphokine-Activated
Oxazoles
Telomerase activity inhibition
Platelet-Derived Growth Factor
Cyclooxygenase 2 Inhibitors
Cell growth
Benzenesulfonates
Cell Cycle
G1 Phase
Membrane Proteins
Selective cyclooxgenase‐2 inhibitor
Cell cycle
biology.organism_classification
Squamous carcinoma
Isoenzymes
Killer Cells
Natural
Endocrinology
Oncology
Epidermoid carcinoma
Cell culture
Cyclooxygenase 2
Head and Neck Neoplasms
Prostaglandin-Endoperoxide Synthases
Cancer research
Carcinoma
Squamous Cell
Female
Anti‐angiogenesis
Cell Division
Zdroj: Japanese Journal of Cancer Research : Gann
ISSN: 0910-5050
Popis: The anti-tumor effect of a selective cyclooxygenase (COX)-2 inhibitor, JTE-522, was examined with the human head and neck squamous cell carcinoma cell line KB. KB cells do not produce prostaglandin (PG)-E2. In vitro, JTE-522 induced an increase of G1 phase-arrested cells, suppression of platelet-derived growth factor (PDGF) production and inhibition of telomerase activity. No cytotoxic effect was detected. In vivo, the growth of the tumor xenografted into nude mice was significantly suppressed by JTE-522. Suppression of angiogenesis at the periphery of the tumor, increase of G1-arrested cells and suppression of telomerase activity were observed, together with an increase of apoptotic cell death in the tumor. Immunological enhancement did not play a role. We concluded that the anti-tumor effect of JTE-522 was caused by anti-angiogenesis action, cell cycle arrest and inhibition of telomerase activity of the tumor cells. These combined effects might induce apoptosis.
Databáze: OpenAIRE
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