Palladium(II)-Catalyzed Mono- and Bis-alkenylation of N-Acetyl-2-aminobiaryls through Regioselective C–H Bond Activation
| Autor: | Huan Chang Hsiao, Yi-Hung Liu, Kou Chi Hsu, Pei Ling Chen, Chih Wei Chou, Cheng Ming Hsieh, Shih-Ching Chuang, Gu Ying Lin, Pratheepkumar Annamalai, Selvam Raju |
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| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Alkene Organic Chemistry chemistry.chemical_element Regioselectivity 010402 general chemistry 01 natural sciences Medicinal chemistry Reductive elimination 0104 chemical sciences Catalysis chemistry Oxidative coupling of methane Solvent effects Selectivity Palladium |
| Zdroj: | The Journal of Organic Chemistry. 83:3840-3856 |
| ISSN: | 1520-6904 0022-3263 |
| Popis: | We developed palladium-catalyzed oxidative coupling of olefins with N-acyl 2-aminobiaryls through a sequence of ortho C-H bond activation/alkene insertion/reductive elimination. Furthermore, we controlled the selectivity of mono- and bis-alkenylation products with the solvent effect. The developed protocol was promising for a broad substrate scope ranging from activated olefins with a wide variety of functional groups to unactivated olefins. |
| Databáze: | OpenAIRE |
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